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Claudia Donnet
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So interesting that two small molecules with some structural similarities present different survival outcomes. I haven't been following every single clinical study, but from your report it seems that the survival has been compared between one of these inhibitors vs. chemotherapy alone. Has any of the studies been done with Tarceva vs Iressa in parallel?
Gefitinib or Chemotherapy for Non–Small Cell Lung Cancer with Mutated EGFR
AstraZeneca's Gefitinib (Iressa) has had a bit of a chequered history since it's fast track approval by the the Japanese Health Authority in 2002 and the FDA in 2003 for non-small cell lung cancer (NSCLC). However, since the phase III trials did not appear to generate a significant overall survi...
Typical cautious statement of a pure academic scientist, although I see that Ciba Geigy Switzerland was involved in this case.
Many of these suggestions appear in the conclusions of many academic papers coming from good labs from all around the world. I wonder if there aren't many diamonds in the rough that have not been picked up by the industry and transformed into a solution for human health. Some academic papers may appear on topics that are not "hot" or "current" at the time and I guess that their findings could pass by, unnoticed. Is industry screening all the literature or does it depend on the academics to have an entreprenurial and/or healing-oriented vision and connect with the industrial world to get their interest?
Understatement of the decade?
At the American Society of Hematology meeting last weekend, I had the pleasure of listening to an enlightening education session on CML from Drs Brian Druker, John Goldman, Moshe Talpaz and Tim Hughes, all leading lights in the field. Prof Goldman's talk was particularly riveting because he alwa...
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Dec 13, 2009
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