I had a issue when i restart the apache after so many years and error was httpd: Syntax error on line 233 of /usr/local/apache/conf/httpd.conf: Cannot load /usr/local/apache/modules/libphp5.so into server: libmysqlclient.so.16: cannot open shared object file: No such file or directory before as i can see the mysql was installed under /usr/local/mysql then i made following changes and then issue fixed. echo "/usr/local/mysql/lib/mysql" >> /etc/ld.so.conf echo "/usr/local/mysql" >> /etc/ld.so.conf ran ldconfig Cheers...