Absolutely +1 for trying to rid your life of as many physical artifacts as possible! However, for me as a music producer, it is unacceptable to produce lossy audio. The media of today is about remixing and mashing up - reencoding audio in a lossy way at every new version is what I call disastrous. Also note that the perception of lossy compression greatly depends on the kind of music. I play the organ, and organ music is especially prone to the artifacts due to MP3 compression.