Have you both not read the abstract of the article? This is not a systematization of any kind. This is a list of main research areas that need to be the focus of investigations and development of late-onset therapies.

1. Not all of those people are old, even if so, it doesn't necessarily mean that they are not capable of looking into the future and seeing how beneficial life extension (and automatical simultaneous health improvement) is. 2. Overpopulation and wars are seeming threats. You can read why in my post About overpopulation. And even military agencies like the Dapartment of Defence invest a lot of money in initiatives like AFIRM, which focuses on regenerative medicine that is meant to significantly improve people's health and extend lives.

I don't think that life can be dramatically extended only by supplements, diet regime, excercise and meditation techniques. Of cource, these things are useful, but they are not enough. Life extension requires extensive scientific research aimed at developing anti-aging therapies that would intervene into the fundamental mechnisms of aging.

This is a fashion fairy tail. Anyway, I'm not sure I understand what you mean.

Well, it depends on how you define caloric deficit. Caloric restriction is when one consumes about 30% less calories, than he normaly does. If one is an athlete, then the rule is still the same I guess, 30% less. I don't know what the avarage calorie intake is in active athletes to provide enough energy. But my guess is that 5000 kcal is far too much, and this regime can't be described as diet restriction. Anyway, I believe more studies are needed to distinguish the role of SIRT1 in low calorie diet and caloric deficit.

Yes, I was) Life is a miracle and we all must make effort to prolong it.

The relationship between the brain and aging is extremely interesting. Maybe, aging is to a large extent goverened by changes in the neuroendocrinal regulation, since it's one of the main regulatory systems in our body. Actually, the relation is in both ways: aging processes influence the brain and visa versa. Also, one of the things that may contribute to aging is the phycological aspect. And Sara, do you really believe in this indian fraud? No-one can survive without food or water for decades, not even for a month. This is a fairy-tale told by mass media or whoever was interested in this story. I just think we must be reasonable. Yes, I know, I also sometimes want to believe in miracles, but I really prefer logic and common sence. It's only the thing that are proven in scientific experiments that can help us prolong our life. Therefore, we need more research into the mechanisms of aging.

I hate to question the opinion of renowned scientists, but I do need to ask - well, what about the segregative type of aging then? It's when a part of the cell population ages, because of the assimetric redestribution of "old", damaged macromolecules between the mother and the dauther cells. I believe this can be seen in bacteria.