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Mark D. Pool, M.D.
Chicago
I'm a pathologist interested in pulmonary pathology and transfusion medicine.
Interests: st. louis cardinals baseball, shakespeare, bluegrass music, playing banjo, gk chesterton, golf, latin and french languages, silent movies
Recent Activity
Video discussing red cell storage lesion
As a follow-up to my post on the red cell storage lesion from a couple days ago, Transfusion News has posted a video interview with Dr. Zimring, the author of the recent article in Blood that I referenced. Continue reading
Posted May 1, 2015 at The Daily Sign-Out
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Reassessment of the red cell storage lesion
James C. Zimring has published a wonderful perspectives article in the April 2, 2015 issue of Blood (abstract) that nicely summarizes what is known about the red cell storage lesion from clinical and experimental studies. However, recent RCTs (ARIPI abstract,... Continue reading
Posted Apr 30, 2015 at The Daily Sign-Out
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New International Society of Blood Transfusion Website
The International Society of Blood Transfusion (ISBT) recently highlighted its new website, which is more user-friendly and has links to other useful content, including their LinkedIn page and recent presentations. You can also register for their "My ISBT" that provides... Continue reading
Posted Mar 9, 2015 at The Daily Sign-Out
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RBC Transfusion Associated with Increased Susceptibility to Lung Inflammation
Another recent article that I finally had a chance to read and ruminate on: Danielle Qing and colleagues from have published an intriguing article in the December 1, 2014 issue of the American Journal of Critical Care and Respiratory Medicine,... Continue reading
Posted Feb 13, 2015 at The Daily Sign-Out
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Procalcitonin in Critically Ill Patients: ProGUARD study results
We recently implemented a procalcitonin assay in my lab in the evaluation of patients with clinically suspected sepsis with undifferentiated infections. How timely then that lead author Yahya Shehabi and members of the ProGUARD study group of the Australian and... Continue reading
Posted Feb 12, 2015 at The Daily Sign-Out
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Effectiveness of crossmatched or HLA-platelets vs. random platelets for refractory patients
Rioux-Massé et al from University of Minnesota Medical Center report in the December 2014 issue of Transfusion (abstract) a retrospective study of 32 patients who had laboratory confirmation of immune-mediated PLT refractoriness, and received platelet transfusion with crossmatched or HLA-matched... Continue reading
Posted Feb 12, 2015 at The Daily Sign-Out
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DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis
In case you may have missed this one, Ivana Yang and colleagues from the University of Colorado have published a fascinating article in the December 1, 2014 issue of American Journal of Respiratory and Critical Care Medicine, "Relationship of DNA... Continue reading
Posted Feb 11, 2015 at The Daily Sign-Out
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Lung Cancer Screening--from the International Association for the Study of Lung Cancer
November is Lung Cancer Awarenesss Month and IASLC has issued some valuable talking points that could be useful for lung cancer screening with patients, colleagues, and the general public. Lung Cancer is the #1 cancer killer in the world, killing... Continue reading
Posted Nov 13, 2014 at The Daily Sign-Out
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Mismatch Repair Status and BRAF Mutation Status in Metastatic Colorectal Cancer Patients: A Pooled Analysis of the CAIRO, CAIRO2, COIN, and FOCUS Studies
http://clincancerres.aacrjournals.org/content/20/20/5322.abstract?etoc Sent from my iPad Continue reading
Posted Oct 15, 2014 at The Daily Sign-Out
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Novel cutaneous and pulmonary syndrome associated with mutations in STING
Fascinating article describing a vasculopathic cutaneous and pulmonary syndrome associated with autosomal dominant mutations in TMEM173, the gene encoding stimulator of interferon genes (STING). An incredible body of work presented with numerous clinical pictures and photomicrographs in the supplementary appendix... Continue reading
Posted Aug 6, 2014 at The Daily Sign-Out
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CFTR: cystic fibrosis and beyond
Excellent recent review of the role of the cystic fibrosis transmembrane conductance regulator in cystic fibrosis. http://erj.ersjournals.com/content/early/2014/06/12/09031936.00228013.abstract Download WebPage.pdf Continue reading
Posted Jul 20, 2014 at The Daily Sign-Out
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The Role of Vascular Endothelial Growth Factor in Pulmonary Arterial Hypertension: The Angiogenesis Paradox
Current review focusing on the enigmatic role of VEGF in the pathogenesis of pulmonary arterial hypertension from American Journal of Respiratory Cell and Molecular Biology published online last month. Abstract Pulmonary arterial hypertension (PAH) is characterized by dysfunctional angiogenesis leading... Continue reading
Posted Jul 20, 2014 at The Daily Sign-Out
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Unopposed Cathepsin G, Neutrophil Elastase, and Proteinase 3 Cause Severe Lung Damage and Emphysema
Interesting abstract from American Journal of Pathology showing evidence for involvement of neutrophils serine proteinases in pathogenesis of emphysema. Abstract Cigarette smoking is a major factor for the development of pulmonary emphysema because it induces abnormal inflammation and a protease-rich... Continue reading
Posted Jul 20, 2014 at The Daily Sign-Out
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Multifocal Micronodular Pneumocyte Hyperplasia Mimicking Miliary TB
Saturday morning interesting case report! Download Multifocal pneumocyte hyperplasia mimicking miliary TB case report Lee 2014 Continue reading
Posted Jun 28, 2014 at The Daily Sign-Out
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SNAI1 functional variant associated with decreased risk for lung cancer
This is an abstract from the January 15, 2014 issue of American Journal of Respiratory and Critical Care Medicino that I just re-discovered this week and relates to one of my ongoing (and unrequited) obsession with epithelial-mesenchymal transition in lung... Continue reading
Posted Jun 26, 2014 at The Daily Sign-Out
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Web-based Tool for Assessing Transfusion Reactions
The Hemovigilance Module of the CDC's National Healthcare Safety Network has an open access Web application for assessing transfusion reactions that is available at www.trddx.com. This tool is based on the NHSN Hemovigilance Module Surveillance Protocol (itself an essential resource).... Continue reading
Posted Jun 26, 2014 at The Daily Sign-Out
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NHLBI Workshop Report: Matrix Biology in Idiopathic Pulmonary Fibrosis
The June 2014 issue of American Journal of Pathology has this state-of-the-art review, based on a recent NHBLI workshop, of the various attributes of the lung extracellular matrix and its role in normal lung and in the development of IPF.... Continue reading
Posted Jun 25, 2014 at The Daily Sign-Out
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Major Driver Mutations in Adenosquamous Lung Carcinomas
The June 2014 issue of Journal of Thoracic Oncology (abstract) features a thorough study of major known driver mutations (EGFR, KRAS, ERBB2, BRAF, PIK3CA, AKT1, RET, and ALK) in a series of 76 patients from Fudan University Shanghai Cancer Center... Continue reading
Posted Jun 23, 2014 at The Daily Sign-Out
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Ancient account of physician subspecialization
This is a follow-up to my recent post on Herodotus describing 6th-century BC Babylonians relying on "social networking" for health care. In Book 2 of The Histories, Herodotus comments on Egyptian medicine (ca. 500 BC). In opposition to Babylonian health... Continue reading
Posted Jun 21, 2014 at The Daily Sign-Out
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Extratumoral lymphatic permeation as prognostic marker in NSCLC
Matsumura and colleagues from the National Cancer Center Hospital East in Chiba, Japan recently reported in the Journal of Thoracic Oncology (abstract) their study of the location of lymphatic permeation in relation to the tumor and the effect on outcome.... Continue reading
Posted Jun 20, 2014 at The Daily Sign-Out
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Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma
Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma https://app.docwi.se/content/2179990/-- Sent from docwi.se – the personalized reading app for physicians on the iPad and iPhone Available in the App Store Sent from my iPad Continue reading
Posted Jun 18, 2014 at The Daily Sign-Out
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Blogging: Is it good or bad for journal article readership?
Thoughtful post regarding the relationship between blogging about academic articles and actual reading of the same. When I blog about an article it is usually to call attention to an interesting, important, and provocative article that the average pathologist may... Continue reading
Posted Jun 18, 2014 at The Daily Sign-Out
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Early adopters of using social networking in health care
I decided to tackle The Histories by Herodotus this summer, after having enjoyed reading Thucydides' The Peloponnesian War last summer, and came across a fascinating description of Babylonian medicine by Herodotus in Book 1 that I connected with social networking... Continue reading
Posted Jun 11, 2014 at The Daily Sign-Out
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Whole genome sequencing not ready for prime time
Brief reaction from The Incidental Economist on recent JAMA article: Whole genome sequencing not ready for prime time. I agree that WGS is not ready for prime-time yet. Routine molecular testing--even for colon and lung in which there are more... Continue reading
Posted Mar 12, 2014 at The Daily Sign-Out
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Mutations in Lung Adenosquamous Carcinomas
Journal of Thoracic Oncology just issued a published ahead-of-print article that examined mutations of most frequent driver mutations seen in pulmonary adenocarcinomas in a series of 76 resected adenosquamous carcinomas of the lung. This is an important study to note... Continue reading
Posted Jan 31, 2014 at The Daily Sign-Out
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