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Zurie
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As someone with a condition that took years to diagnose, I find this show riveting. I have autonomic dysfunction and small fiber peripheral neuropathy. For years I went to specialists who treated symptoms seperately and since at that point I was diagnosed with "fibromyalgia", I wasn't treated so nice. It took a car accident after blacking out and finding a neurologist who knew a neuromuscular specialist, who is now my specialist, after twelve different doctors either told me I had a problem, it wasn't that bad, and I would have to learn to live with the dizziness, burning pain, "misfiring" nerves, weird sweating in only my hands and feet, and problems with my digestive system. I'm glad I got an answer, but I wish more doctors would listen to their patients or at least know how to tell the difference between persistence and catastrophizing.
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No what is obvious is that you take statements that I clearly stated were overstatements on purpose for effect and latch on to them to prove some point when the original statement I made, over and over I might add, is that the idea has POTENTIAL. I stated my reasons for feeling this way and instead of looking at the argument that A: limbic and endocrine relationship is so linked and intricate that any disruption can have terrible consequences and B: there is research, not just my own hypothesis, that supports this. I did link an article on my second or third post and the expose done by the Milwaukee Journal Sentinel, where these reporters did months and months of investigative journalism on the inepititude of the EPA/FDA on this issue. I did not only identify BPA I said all endocrine disruptors. Instead of arguing based on the original idea of mine, you latch on to a few statements to try to invalidate the whole thing. I already said 90% was an overstatement, but considering the fact that known mutagens are in our air, water, food, and basically everything we come into contact with since the wonderful age of "technology" we can expect to have consequences that are bad even if we do make some gains in the process. My main argument is there is enough evidence out there that says this stuff isn't safe. There was push back for years on lead, and yes our taxpayer dollars still pay for the clean up and suing that industry didn't eradicate the danger, tobacco was called "safe" and even used to treat asthma. When we have thousands of chemicals that no one truly knows are safe for human consumption and companies who profit from these chemicals funding the research, lobbying the government to allow them to sell their products, and basically having no real reason to do their duty as citizens because in America "the markets fix everything"; there is extreme concern. I get upset so what, why? Because my main argument and point is ridiculed instead of talking about how the possibility that disrupting the negative feedback pathways of the neuroendocrine system could have developmental effects there is this smear campaign launched to pick at and misrepresent my statements. I hope you feel real good about yourself as you smugly look in the mirror thinking you've accomplished something. Meanwhile as my colleages and I are in the lab working on research doing what we can to protect the future of this country, you can go ahead defending big business, the special interest lobbying groups that run this country (which I bet a good buck you are a part of), and when the science catches up you will see you are mistaken. There also has been studies that say the rate of autism HAS gone up not because of refined diagnoses but because of "something" they cannot yet define. Genetics plays a part and when you have mutagens in our environment it is not a far stretch from the imagination that it could be the cause of some cases. I will not waste my time and energy giving my evidence when the evidence I have given is completely ignored. By the way the CD4/CD25 receptors on the Treg cells are important in immune function and their mutations have been linked with an increased rate of asthma and allergies. The CD4 receptor is also one of the receptors that allows HIV to enter the macrophage and that particular receptor causes HIV to turn into full blown AIDS more rapidly. They found this out because they came up with a drug called marivoric that blocks the CCR5 co-receptor, which is responsible for HIV infiltration into the macrophage in some strains of HIV-1, when they blocked the receptor in some patients who had the CD4 tropic variant not only did they disease act more rapidly but more aggresively. So let's all mutate our CD4 receptors on our macrophages, maybe we won't get ASD, especially since it is the embryonic development that concerns endocrinologists regarding ASD, but hey we all could die because our immune cells aren't up to snuff. You will find that in the study I posted above regarding CD4/CD25 cell receptors. Just a side note: I hope your job doesn't require being detail oriented because if it did I wouldn't have had to explain my comments yet again...
Toggle Commented Feb 24, 2009 on Vaccines Didn't Cause Autism at Skeptico
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BTW distilled water is not good for you and I'm not someone who thinks naturally only is necessary, I plan to prescribe these drugs I think I have the right to expect that I won't seriously harm my patients.
Toggle Commented Feb 20, 2009 on Vaccines Didn't Cause Autism at Skeptico
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Did you read the study? Did you look up the links that are there? You don't know what Treg cells are and you are saying that BPA is safe? You cannot sit here and tell me that the govt has it right when the investigative reporting done by the MilwaukeeJS has shown everything I don't need to here right now. You refuse to read the watchdog report why? Because then you'd see I'm right? Because then you'd have to give up the easy notion that the govt protects you and your offspring over special interests? You enjoy being ignorant that is evident! Don't knock my research because you don't "understand" it. I also work in the pharmaceutical industry, in a pharmacy, at the present moment while I'm in school. I work with a Pharmacist who has worked in research before working in the community. Even HE understands and appreciates the politicizing of the chemical/pharmaceutical industry. Don't tell me I'm making baseless claims when you are the one who can't even explain the science I am giving you. You can't even claim to begin to know if what anyone is saying when it comes to science is true or not. Have you ever read a study? A peer reviewed study? They contain citations from OTHER studies with references and such, in the History and Conclusion sections they refer to recent research constantly. YOU CANNOT DO A SCIENTIFIC STUDY WITH ONLY YOUR OWN DATA. Seriously how you can say that the studies I cited only had something to do with urine concentrations, you obviously missed A LOT OF INFORMATION!!!! Ignorance is not bliss my friend. I did not pull this one out of my butt, just because you refuse to inform yourself doesn't mean I am going to waste my time proving it to you when I HAVE given you the information and either you are too stubborn or too ignorant to find it from there. Good luck trusting the companies who pose to profit from these chemicals THAT DO MIMICK HORMONES OR SURPRESS THEM, in fact give them in large quantities to your offspring and lets see what happens in 20 years. Good luck sounding like an idiot citizen who really believes the government has your back and will not allow anything to happen to you. You obviously don't know much about the FDA/EPA, having ONE product approved means nothing when EVERYDAY I deal with recalled products because someone dropped the ball. The recent one that comes to mind= Ethex. And Yes I have every right to expect the government agencies I pay to keep there should do their job and be damn sure the people they are exposing to their products are not going to create a situation that the rest of the country has to pay for later. Good luck with your obvious head in the sand.
Toggle Commented Feb 20, 2009 on Vaccines Didn't Cause Autism at Skeptico
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I am proposing regarding the FDA and EPA that former pharmaceutical heads make decisions based on drugs produced by their former colleagues. I am suggesting that testing should be done by a verifiable source chosen by someone other than the pharmaceutical company. I am suggesting that instead of proving something safe we are proving it isn't harmful with not enough data. I am suggesting that the US system of approving drugs and chemicals is antiquated and with the new available technology we need a new approach so we can avoid situations like Ketek and Vioxx, there is no argument either that Ketek's risked were downplayed by the pharmaceutical company. Our taxdollars PAY TO CLEAN UP THE MESS of these companies when something is uncovered. How many lead poisoned children in the inner city are being diagnosed as such daily? I said "potentially" in the first place and my discussion was on all endocrine disruptors not BPA only. I am not the only one suggesting this. My point about Africa was not that BPA causes intestinal issues, my point which I clearly failed to make is the crap we have in our soil, water (which they don't want us flushing Premarin or estradiol either because they cannot filter it out of the water), air, etc that are more toxic than in places not touched by "technology". The best I have is citations not actual links because I didn't access them via Internet but through Ebsco. Endo, Y., Kimura, N., Ikeda, I., Fujimoto, K., & Kimoto, H., (2007, February). Adsorption of bisphenol a by lactic acid bacteria, Lactococcus strains. Applied Microbiology and Biotechnology 74(1), pp. 202-207. Mahalingaiah, S., Meeker, J., Pearson, R., Calafat, A., Ye, X., Petrozza, J, et al. (2008, February). Temporal Variability and Predictors of Urinary Bisphenol A Concentrations in Men and Women [Electronic Version]. Environmental Health Perspectives, 116 (2), 173-178. Yan, H., Takamoto, M., & Sugane, K., (2008, April). Exposure to bisphenol a prenatally or in adulthood promotes T(H)2 cytokine production associated with reduction of CD4CD25 regulatory T cells. Environmental Health Prospectives, 116(4), pp514-519. I am not saying I know this for sure I am saying it has potential as an idea. I was arguing why based on reasons that make sense to me: limbic and endocrine relationship. I don't expect nothing to have a side effect but I do expect a known mutagen, which is why I included the MSDS not the threshold, to be studied further when they haven't done much about it since ten years or so ago. There was a big expose done in the Milwaukee Journal Sentinel and the link is here: http://www.jsonline.com/watchdog/34405049.html
Toggle Commented Feb 16, 2009 on Vaccines Didn't Cause Autism at Skeptico
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Here's the MSDS link for BPA btw http://terpconnect.umd.edu/~choi/MSDS/Sigma-Aldrich/BISPHENOL%20A.pdf
Toggle Commented Feb 15, 2009 on Vaccines Didn't Cause Autism at Skeptico
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If you'd like me to link all my research then I will. I guess I'm of the mind that the US govt hasn't proven themselves as capable of making a scientific decision based on facts and not profit potential. If you believe the crap they tell you then I'm sorry you belong in the same category as them. Have you read any of the research on the subject? Or have you taken the EPAs, might I add they are BROKE, word for it? They don't do the studies themselves, neither does the FDA on new pharmaceuticals, we see how that has turned out recently. Don't insult my intelligence, integrity, or passion because you are some naysayer who thinks "everything is ok" and you don't see the trees just the forest. Maybe right now we aren't dead from overexposure but maybe you don't care if the human race overexposes itself to death. My 90% number was an overexaggeration based on the fact I believe all mutations occur because of some environmental exposure, whether viral, bacterial, chemical, nutritional, or anything else that affects the human body. We don't have historical data that shows symptoms of autism existed on this scale in written records that have existed for 6,000+ years. It is a developmental brain disease that we know, and we cannot rule out endocrine disruptors, not just BPA but phthalates and anything else that tends to bioaccumulate. It just isn't natural and now we have all this disease, in fact you don't find many intestinal issues we have here in the US in places in Africa that are indigenous, explain that?
Toggle Commented Feb 15, 2009 on Vaccines Didn't Cause Autism at Skeptico
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I'm not suggesting BPA is the only cause, I am saying BPA coupled with phlalates while the child is a fetus in utero (where any change in the normal amounts of estrogen/testosterone, T3, T4, TSH, FSH, any of the horomones that regulate fetal development is a very good candidate. It would be great to convince the "right" that we should take zygotes that haven't differentiated yet and expose some to the industrial chemiclas and not do so to others so we could see but unfortunately science doesn't trump emotions even though it could save countless other lives. Maybe I assumed because I am pretty well versed in human biology and it was a "duh" idea to me it would be to everyone else. I assumed if someone commented on any form of etiology they'd know what they were talking about. Genetic? very probable but HOW did the gene mutate? What is the potential future ramifications? If we don't find out for sure what will our world be in 100 years? 90% autistic people? That is scary.... My whole point was the link between the endocrine and limbic system has been proven. There are abnormalaties within the limbic system of autistic children right? Well linking endocrine disruption, which helps regulate limbic activity due to the many negative/positive feedback pathways in the body, seems logical to me.
Toggle Commented Feb 14, 2009 on Vaccines Didn't Cause Autism at Skeptico
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And on that note I speak with intensity because I find it absolutely outragious that our government who is supposedly looking out for us continues to downplay these things as well as take the chemical/pharmaceutical companies word for it that these chemicals are safe (based on 3 studies out of 3,000+ saying the contrary). It pisses me the **** off because as a student in the medical profession, working towards MSN, I saw these things awhile ago when we've discussed them among my peer groups and since I have an interest in working as a practitioner in juvenile endocringology, it interests me greatly. So it is the activist inside me that sounds intense but hey everyone is entitled to be passionate about something. I really don't think people understand how for so long people don't mean anything to the govt of the US just money. If that isn't evident now with everything else going on I don't know what is.
Toggle Commented Feb 14, 2009 on Vaccines Didn't Cause Autism at Skeptico
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Well I can find you more because on this one I'm not talking out of my backside I really have done some critical thinking while studying physiology AND have done research on the existing research. I'm not a wacko out there with some far out theory, there is basis for my hypothesis.
Toggle Commented Feb 14, 2009 on Vaccines Didn't Cause Autism at Skeptico
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But maybe by some of your accounts the EPA has it right and we should TRUST them....(coughs *lead* coughs)
Toggle Commented Feb 14, 2009 on Vaccines Didn't Cause Autism at Skeptico
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I'd like for you to read this research article before you conclude that my interpretation of the facts is incorrect. There is proof scientifically that screwing with the endocrine system has long term effects just ask body builders who use steroids. What happens to their psyche? One example would be Chris Benoit. When we have plastics that mimick estrogens and suppress testosterone and they are all around us in everything it is like giving children birth control pills... Should we do that too and say it is ok and won't cause any problems? Honestly? http://www.ehponline.org/members/2003/6601/6601.html
Toggle Commented Feb 14, 2009 on Vaccines Didn't Cause Autism at Skeptico
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I think the focus of vaccines causing autism is so off its ridiculous. Right in front of our eyes we've had the answer, potentially in my humble opinion, this disease has affected thousands more children since the 90's right? Well what changed in our environment? I'll tell you...We started using plastics and vinyls in everything. PVC piping in houses for water, baby bottles made out of BPA. BPA (bisphenol A) is an estrogen mimicking compound that bind to estrogen receptors and the normal enzymes that remove endogenous estrogen from the receptor cannot remove it, the receptor stays activated. Couple that with vinyl window treatments, floors, piping, etc. phlalates in the vinyl causes testosterone suppression. If the endocrine system, which is extremely closely linked to the lymphatic system in the brain, they work together to create normal body functions, the lymphatic system is important for emotion and memory, if you block the hormones that activate this system you WILL have problems with your lymphatic system. We need to start checking these kids hormone levels and find out how much vinyl and PVC or BPA they may have in their bodies. There is research indicating a "pro-biotic" used to make cheese, lactococci acutally binds with (adsorbs) BPA and removes it from the body. Technology is great but pick your poison carefully not only has this link been suggested but also juvenile diabetes.....food for thought!
Toggle Commented Feb 13, 2009 on Vaccines Didn't Cause Autism at Skeptico
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