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Clarence
Los Angeles - Hollywood. California
Recent Activity
2017_El Agha CSC 2017 from Saverio Bellusci, Ph D on Vimeo. 2017_El Agha_Cell Stem Cell. We have used genetic engineering in mice to identify precursor cells for activated myofibroblasts and investigate their fate in a reversible model of lung fibrosis. Our findings emphasize the phenotypic plasticity of lipogenic and myogenic lung fibroblasts and indicate that PPARg agonists might be beneficial in treating IPF. Continue reading
Posted Apr 12, 2017 at Bellusci lab
2017_Moisenko_StemCells_v3 from Saverio Bellusci, Ph D on Vimeo. 2017_Moiseenko_Stem cells The developmental origin of the smooth muscle cells in the lung is still controversial. We used a lineage-tracing based approach combined with immunofluorescence, FACS and gene arrays to quantify the respective contribution of different mesenchymal progenitors to the SMC lineage. We also compared, at E18.5, the transcriptomic profile of alveolar myofibroblast progenitors versus bone fide ACTA2+ cells (vascular and airway SMC). Continue reading
Posted Apr 12, 2017 at Bellusci lab
2015_Al Alam et final from Saverio Bellusci, Ph D on Vimeo. 2015_Al Alam et al_Development Although lipofibroblasts were initially believed merely to assist type 2 alveolar epithelial cells in surfactant production during neonatal life, recent evidence suggests that these cells are indispensable for survival and growth of epithelial stem cells during adulthood. We show that a population of lipid-droplet-containing stromal cells emerges in the developing mouse lung between E15.5 and E16.5. This is accompanied by significant upregulation, in the lung mesenchyme, of peroxisome proliferator-activated receptor gamma (master switch of lipogenesis), adipose differentiation-related protein (marker of mature lipofibroblasts) and fibroblast growth... Continue reading
Posted Apr 12, 2017 at Bellusci lab
Visiting Professor Appointment (January 3, 2018 - February 8, 2019) (January 1, 2017 - December 15, 2017) (November 1, 2015 - June 30, 2016) Mongolian National University of Medical Sciences School of Public Health Ulaanbaatar, Mongolia Course Design and Teaching:... Continue reading
Posted Apr 4, 2017 at Clarence Wigfall
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Class Photo Completion of Introduction to Public Health and Science Communication Mongolian National University of Medical Sciences School of Public Health With one exception all those taking this class were faculty and practicing health professionals. There are a number who... Continue reading
Posted Jan 12, 2016 at Clarence Wigfall
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Ulaanbaatar 8:30am January 9, 2016 Getting ready to go into the Ger Districts -24F Extreme Pollution AQ reading approximately 235 Inside my Apartment view from my apartment window this morning The Ger Districts are where most of the heavy pollution... Continue reading
Posted Jan 9, 2016 at Clarence Wigfall
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Vegetarian in Ulaanbaatar? What between teaching and student conferences? Egg Salad and Mochas! Continue reading
Posted Jan 8, 2016 at Clarence Wigfall
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Eagle News- Guest Hour Interview from Beautiful Downtown Ulaanbaatar Mongolia Actually, it is a beautiful downtown. Eagle news was intrigued by the our first of its kind, Communication for Public Health and Science class at the National University of Medical... Continue reading
Posted Jan 6, 2016 at Clarence Wigfall
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Exciting Days teaching Introduction to Public Health and Science Communication Mongolian National University of Medical Sciences School of Public Health The class is primarily made up of Public Health faculty, including Medical Doctors and Public Health practitioners. We have Medical... Continue reading
Posted Jan 5, 2016 at Clarence Wigfall
Visiting Professor Appointment Mongolian National University of Medical Sciences School of Public Health Ulaanbaatar, Mongolia Course Design and Teaching: "Introduction to Science and Public Health Communication." I conduct this class both online and travel to Mongolia to provide lectures and... Continue reading
Posted Nov 4, 2015 at Clarence Wigfall
See Selected Projects at Advanced Scientific FX.com Continue reading
Posted May 29, 2015 at Clarence Wigfall
Clarence has shared their blog Raw Data Visualized
May 26, 2015
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In Denver for 2015 American Thoracic Society International Conference will present: Video Visualization of the Airways and Alveolar Structures Using High-Resolution microCT Data and Digital Rendering Was cold and damp Saturday and Sunday evening Continue reading
Posted May 18, 2015 at Clarence Wigfall
Lung Video Featured on the National Institutes of Health NIH Director's Blog Continue reading
Posted Feb 18, 2015 at Clarence Wigfall
miR142 from Saverio Bellusci, Ph D on Vimeo. We found that microRNA142-3p is expressed at high level in the embryonic lung mesenchyme. This paper reports the role in vitro of miR142 during early lung development using a knockdown approach. We demonstrate that Adenomatous Polyposis Coli (Apc) is the major target of miR142. Accordingly to Apc's role in canonical Wnt signaling, miR142 knockdown-associated Apc up-regulation leads to inhibition of Wnt signaling. Such inhibition leads to arrested proliferation and premature differentiation of airway smooth muscle cells progenitors. We also show that the effect of miR142 knock down can be rescued by the... Continue reading
Posted Nov 29, 2014 at Bellusci lab
Saverio Bellusci interviews Clarence Wigfall from Saverio Bellusci, Ph D on Vimeo. Saverio Bellusci interviews former student, Clarence Wigfall, about his impressions of joining the Bellusci Lab in Los Ageles, California and spending 4 years working and studying there. Wigfall won a 2014 Federation of American Societies For Experimental Biology (FASEB) BioArt Award for his work in creating the video - Distal Lung Airway - from microCT scans, resolution +/- 5 microns. Wigfall is, as of, November 2014, completing an MPH and doing an Applied Social Psychology PhD at Claremont Graduate University in Southern California Continue reading
Posted Nov 29, 2014 at Bellusci lab
Lung Video picked as a winner of the 2014 Federation of American Societies for Experimental Biology BioArt click this link - then Scroll down to the videos - Continue reading
Posted Oct 9, 2014 at Clarence Wigfall
2014 Gordon Conference - Fibroblast Growth Factors in Development & Disease Re-Cap Held March 2-7, 2014 Ventura, CA Clarence Wigfall, of Advanced Science Communications, interview with Dr. Bellusci Re-Capping the 2014 Gordon Conference on Fibroblast Growth Factors. GRC ReCap by Saverio Bellusci, PhD from Saverio Bellusci, Ph D on Vimeo. The Gordon Research Seminar on Fibroblast Growth Factors in Development & Disease is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. The focus of this meeting was emerging research on molecular... Continue reading
Posted Jul 18, 2014 at Bellusci lab
Lineage Tracing Lineagetracing 2 from Saverio Bellusci, Ph D on Vimeo. Preview - Paper accepted for Publication. Link to Journal up soon. Continue reading
Posted Jul 18, 2014 at Bellusci lab
Transient Inhibition FGFR2B AER FGFR2B AER Transient Inhibition from Saverio Bellusci, Ph D on Vimeo. Preview - Paper accepted for Publication. Link to Journal up soon. Soula Danopoulos lead author Continue reading
Posted Sep 18, 2013 at Bellusci lab
Clarence Wigfall Interview with Saverio Bellusci, PhD Gordon Conference - Fibroblast Growth Factors in Development & Disease March 2-7, 2014 Ventura Beach Marriott Ventura, CA The Gordon Research Seminar on Fibroblast Growth Factors in Development & Disease is a unique... Continue reading
Posted May 7, 2013 at Clarence Wigfall
Clarence Wigfall Interview with Saverio Bellusci, PhD Gordon Conference - Fibroblast Growth Factors in Development & Disease March 2-7, 2014 Ventura Beach Marriott Ventura, CA The Gordon Research Seminar on Fibroblast Growth Factors in Development & Disease is a unique forum for graduate students, post-docs, and other scientists with comparable... Continue reading
Posted May 7, 2013 at Advanced Science Communications
Gordon Conference - Fibroblast Growth Factors in Development & Disease March 2-7, 2014 Ventura Beach Marriott Ventura, CA Clarence Wigfall, of Advanced Science Communications, interview with Dr. Bellusci about the upcoming Gordon Conference on Fibroblast Growth Factors. The Gordon Research Seminar on Fibroblast Growth Factors in Development & Disease is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. The focus of this meeting is emerging research on molecular mechanisms of FGF signaling and the involvement of these pathways in normal development... Continue reading
Posted May 7, 2013 at Bellusci lab
Saban Research Institute Developmental Biology/Regenerative Medicine 2013 Annual Retreat Ahmed El-Hashash, PhD Molecular control of stem/progenitor cell behavior and lung morphogenesis Introduction by David Warburton, MD Program Director, Developmental Biology/Regenerative Medicine Department, Saban Research Institute. Dr. Ahmed El-Hashash, Assistant Professor of Stem Cell Biology and Regenerative Medicine at the University... Continue reading
Posted May 4, 2013 at Advanced Science Communications