Hi Maya- When it comes to producing content for your organization, the ultimate goal is to keep the audience/donors engaged, which will hopefully lead to more support (and donations). While we don't think it's necessarily inappropriate to have the donate now call-to-action front and center-- as that is often the norm with others NPO's-- it could dilute the message within the newsletter. What we'd suggest is if your newsletter is captivating/uplifting and tells a great story that prompts supporters to become recurring donors, then saving the donate button for the end is the best bet. Good luck!